Regulation of phospholipase C-activating G protein-coupled receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of phospholipase C-activating G protein-coupled receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CFAP70, PPM1L, and ZNF606, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CFAP70 grouped by Regulation of phospholipase C-activating G protein-coupled receptor signaling pathway-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CFAP70 →	+0.894	+0.826	<.001	.007	3	4
BREAST	PPM1L →	+0.755	+0.824	.006	.003	3	4
BREAST	ZNF606 →	+1.296	+0.812	<.001	.001	3	4
BLOOD_Leukemia	SGSM3 →	+0.852	+1.136	.003	.002	3	4
LARGE_INTESTINE	CHRNA10 →	+0.425	+1.047	.008	.004	3	4
LARGE_INTESTINE	JMY →	+0.796	+0.770	<.001	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CFAP70 by Regulation of phospholipase C-activating G protein-coupled receptor signaling pathway activity — BREAST

Explore this box plot interactively →