Regulation of long-term synaptic depression

Across TCGA patient cohorts, RNA activity of the Regulation of long-term synaptic depression pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HK3, RNF213, and CTSA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of long-term synaptic depression activity versus HK3 in PDAC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	HK3 →	+0.621	+0.056	.002	<.001	3	6
LSCC	RNF213 →	+0.344	+0.066	<.001	<.001	3	5
UCEC	CTSA →	+0.246	+0.042	.001	.006	2	6
BRCA	PARP9 →	+0.329	+0.045	.002	.003	3	5
PDAC	AKAP11_S133 →	+0.346	+0.051	.001	<.001	3	5
PDAC	FCER1G →	+0.578	+0.046	.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900452 vs HK3 — PDAC

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