Regulation of long-term synaptic depression

Across TCGA cell cohorts, RNA activity of the Regulation of long-term synaptic depression pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDRG4, SLC2A1, and RNF24, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NDRG4 grouped by Regulation of long-term synaptic depression-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	NDRG4 →	+2.786	+0.647	<.001	.006	3	4
SOFT_TISSUE	SLC2A1 →	-1.682	-1.167	.001	.001	3	4
SOFT_TISSUE	RNF24 →	-1.325	-1.247	<.001	<.001	3	4
LUNG_NSCLC_LUAD	OSBPL3 →	-0.780	-0.612	.009	.009	3	4
PANCREAS	TIMELESS →	+0.756	+1.201	.007	.001	3	4
PANCREAS	MED14OS →	+0.353	+1.008	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NDRG4 by Regulation of long-term synaptic depression activity — LUNG_SCLC

Explore this box plot interactively →