Q-omics provides the consensus-scored MED14OS profile across patient tissues and cancer cell-line models. MED14OS expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in LGG. Among the 18 cancer types available for tumor–normal comparison, MED14OS is differentially expressed in 11, with the highest sampling consensus in THCA. Additionally, MED14OS RNA expression shows 17,487 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight LGG, THCA, and UVM as cancer lineages where MED14OS shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MED14OS — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MED14OS survival associations across molecular data types. MED14OS RNA expression shows survival associations in the most cancer types (23). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MED14OS RNA expression–survival associations across cancer types. High MED14OS expression shows unfavorable associations in LGG, ACC and COAD, but favorable associations in PAAD, THCA and CHOL. The LGG Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify LGG as the clearest survival context for MED14OS RNA expression.
This table summarizes MED14OS tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for MED14OS. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MED14OS shows lower tumor expression in THCA, KICH, BLCA, LUAD, KIRP and BRCA. The THCA box plot shows higher MED14OS RNA expression in normal versus tumor tissue (log2 FC = −1.216, t-test p < 0.001).
This table shows molecular features associated with MED14OS in patient tissues and cancer cell lines. In patient samples, MED14OS shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, MED14OS RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Lymphoma.
