Positive regulation of defense response to bacterium

Across TCGA patient cohorts, RNA activity of the Positive regulation of defense response to bacterium pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLEC7A, AQP9, and CD33, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of defense response to bacterium activity versus CLEC7A in LSCC (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CLEC7A →	+0.894	+0.161	<.001	.003	3	7
GBM	AQP9 →	+1.223	+0.265	.001	<.001	3	6
GBM	CD33 →	+0.561	+0.242	<.001	<.001	3	6
BRCA	ARHGAP9 →	+0.786	+0.229	<.001	<.001	3	6
GBM	LILRB2 →	+0.673	+0.191	.001	.005	3	6
COAD	C1orf162 →	+0.904	+0.229	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900426 vs CLEC7A — LSCC

Explore this scatter interactively →