Positive regulation of defense response to bacterium

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of defense response to bacterium pathway differs between tumor and matched normal tissue in 11 of the 18 cancer types tested.

The strongest signal is observed in thyroid carcinoma (THCA), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KICH and BRCA, show the opposite pattern, with lower activity in tumor tissue.

THCA, KICH, and BRCA show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
THCA	Female	II,III,IV	+0.086	<.001	11	view →
KICH	Male	All	−0.148	<.001	8	view →
BRCA	All	III,IV	−0.096	<.001	8	view →
HNSC	Female	All	+0.052	.005	7	view →
LUSC	All	II,III,IV	−0.076	<.001	6	view →
COAD	All	All	−0.029	.004	6	view →
KIRP	All	All	−0.068	<.001	4	view →
LUAD	All	IV	−0.084	.016	2	view →
UCEC	All	All	−0.045	.025	2	view →
STAD	All	IV	−0.089	.037	1	view →
KIRC	All	All	+0.024	.023	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 11 strongest of 11 lineages.

GO:1900426–THCA

Open the THCA breakdown →