Positive regulation of defense response to bacterium

Across TCGA cell cohorts, RNA activity of the Positive regulation of defense response to bacterium pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DCUN1D1, EGR1, and GATD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DCUN1D1 grouped by Positive regulation of defense response to bacterium-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DCUN1D1 →	-0.394	-1.019	<.001	.002	3	4
BLOOD_Myeloma	EGR1 →	-2.656	-1.857	<.001	<.001	3	4
BLOOD_Myeloma	GATD1 →	+0.595	+1.529	.005	.006	3	4
LUNG_NSCLC_LUAD	TM9SF4 →	+0.675	+0.890	.008	.002	3	3
LUNG_NSCLC_LUAD	MDH1 →	-0.634	-0.792	<.001	.001	3	3
LUNG_NSCLC_LUAD	ZFYVE27 →	+0.719	+1.024	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DCUN1D1 by Positive regulation of defense response to bacterium activity — SKIN

Explore this box plot interactively →