Negative regulation of defense response to bacterium

Across TCGA patient cohorts, RNA activity of the Negative regulation of defense response to bacterium pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HTATIP2, MICALL1, and ARG2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of defense response to bacterium activity versus HTATIP2 in HNSC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HTATIP2 →	+0.341	+0.077	<.001	<.001	3	5
HNSC	MICALL1 →	+0.226	+0.044	.002	.004	3	5
LSCC	ARG2 →	+0.875	+0.129	<.001	<.001	3	5
OV	HSPA12B_S434 →	-0.726	-0.045	.003	.008	3	4
BRCA	ATP1A1 →	+0.501	+0.051	.002	.004	3	4
HNSC	ACO1 →	-0.189	-0.042	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900425 vs HTATIP2 — HNSC

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