Negative regulation of defense response to bacterium

Across TCGA patient cohorts, RNA activity of the Negative regulation of defense response to bacterium pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNN1, MADD, and DUSP7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of defense response to bacterium activity versus CNN1 in PDAC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CNN1 →	+0.590	+0.177	<.001	.001	3	5
UCEC	MADD →	-0.374	-0.230	.001	.008	3	4
UCEC	DUSP7 →	+0.323	+0.274	.002	.001	3	4
UCEC	LINC01198 →	+0.405	+0.314	.008	.008	3	4
UCEC	PTHLH →	+0.757	+0.265	.007	.008	3	4
BRCA	MT-TC →	+1.018	+0.204	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900425 vs CNN1 — PDAC

Explore this scatter interactively →