Negative regulation of defense response to bacterium

Across TCGA cell cohorts, RNA activity of the Negative regulation of defense response to bacterium pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYL6B, TNFRSF11A, and FKRP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MYL6B grouped by Negative regulation of defense response to bacterium-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	MYL6B →	-0.515	-1.298	.003	.003	3	5
STOMACH	TNFRSF11A →	-1.878	-1.162	.005	.001	3	4
STOMACH	FKRP →	+1.359	+1.185	.003	.004	3	4
BLOOD_Leukemia	KLHL32 →	-0.284	-1.223	.005	.005	3	4
OESOPHAGUS	DUSP9 →	+1.280	+1.078	.001	.001	3	4
LARGE_INTESTINE	MIR1915HG →	+1.452	+0.974	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MYL6B by Negative regulation of defense response to bacterium activity — LIVER

Explore this box plot interactively →