Regulation of cellular response to oxidative stress

Across TCGA patient cohorts, RNA activity of the Regulation of cellular response to oxidative stress pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NFAT5, DYNC1LI2, and RUFY1-AS1, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cellular response to oxidative stress activity versus NFAT5 in THYM (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	NFAT5 →	+1.842	+0.044	<.001	<.001	3	28
THYM	DYNC1LI2 →	+1.640	+0.044	<.001	<.001	3	27
KIRC	RUFY1-AS1 →	+0.691	+0.042	<.001	<.001	3	27
UVM	DMXL2 →	+1.218	+0.042	<.001	<.001	3	26
UVM	PIK3C2A →	+1.464	+0.033	<.001	<.001	3	26
SARC	DLEU2L →	+0.401	+0.021	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900407 vs NFAT5 — THYM

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