Regulation of cellular response to oxidative stress

Across TCGA patient cohorts, RNA activity of the Regulation of cellular response to oxidative stress pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GTF2F1, ACSL1, and CHERP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cellular response to oxidative stress activity versus GTF2F1 in GBM (Pearson r = -0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GTF2F1 →	-0.305	-0.027	<.001	.009	3	6
BRCA	ACSL1 →	+0.413	+0.030	<.001	<.001	3	6
COAD	CHERP →	-0.201	-0.046	<.001	<.001	3	6
GBM	TBC1D1 →	+0.228	+0.034	.004	.008	3	5
COAD	RPS2 →	-0.171	-0.034	.001	<.001	3	5
COAD	RSU1 →	+0.406	+0.038	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900407 vs GTF2F1 — GBM

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