Regulation of cellular response to oxidative stress

Across TCGA cell cohorts, RNA activity of the Regulation of cellular response to oxidative stress pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNJ15, MRPL17, and NHSL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCNJ15 grouped by Regulation of cellular response to oxidative stress-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	KCNJ15 →	-3.800	-1.511	.002	.005	3	3
BLOOD_Myeloma	MRPL17 →	+0.855	+1.651	.006	.001	3	3
OESOPHAGUS	NHSL1 →	+1.176	+0.321	<.001	.002	3	3
OESOPHAGUS	CST6 →	-4.137	-0.341	.002	.001	3	3
URINARY_TRACT	UQCC2 →	+0.556	+1.817	.006	.001	3	3
OVARY	PDCD1LG2 →	-1.070	-0.684	.009	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCNJ15 by Regulation of cellular response to oxidative stress activity — URINARY_TRACT

Explore this box plot interactively →