Regulation of cellular response to oxidative stress

Across TCGA cell cohorts, RNA activity of the Regulation of cellular response to oxidative stress pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AFAP1, IFT43, and GMDS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cellular response to oxidative stress activity versus AFAP1 in SKIN (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	AFAP1 →	-2.253	-0.863	<.001	.007	3	4
KIDNEY	IFT43 →	+0.716	+1.918	.006	<.001	3	3
BONE	GMDS →	-0.530	-1.606	<.001	<.001	3	3
LIVER	OXSM →	+0.613	+1.693	<.001	<.001	3	3
LIVER	HTD2 →	+0.492	+1.252	.002	.003	3	3
KIDNEY	QRICH1 →	+1.093	+2.039	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900407 vs AFAP1 — SKIN

Explore this scatter interactively →