Positive regulation of long-term synaptic potentiation

Across TCGA patient cohorts, RNA activity of the Positive regulation of long-term synaptic potentiation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KIF13B_S1379, MME, and PREPL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of long-term synaptic potentiation activity versus KIF13B_S1379 in GBM (Pearson r = -0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	KIF13B_S1379 →	-0.360	-0.060	<.001	<.001	3	5
LSCC	MME →	+0.806	+0.038	<.001	<.001	3	4
OV	PREPL →	+0.220	+0.034	.005	.004	3	4
CCRCC	FCGR3A →	-0.372	-0.043	.003	.005	3	4
CCRCC	IL18 →	-0.512	-0.050	<.001	<.001	3	4
GBM	TLN1 →	-0.189	-0.046	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900273 vs KIF13B_S1379 — GBM

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