Positive regulation of long-term synaptic potentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of long-term synaptic potentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDE9A, TRIM31, and AGBL3, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PDE9A grouped by Positive regulation of long-term synaptic potentiation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PDE9A →	-0.514	-1.712	<.001	<.001	3	12
CNS	TRIM31 →	-0.252	-1.365	<.001	<.001	3	9
OVARY	AGBL3 →	-0.478	-1.804	<.001	<.001	3	9
OVARY	PLAAT4 →	-0.416	-1.457	.001	<.001	3	8
BLOOD_Leukemia	NPTN →	-0.297	-1.091	.002	.003	3	8
BLOOD_Myeloma	GTPBP1 →	-0.520	-2.293	.009	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PDE9A by Positive regulation of long-term synaptic potentiation activity — OVARY

Explore this box plot interactively →