Positive regulation of long-term synaptic potentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of long-term synaptic potentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMGCR, PIGC, and SLC35G1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HMGCR grouped by Positive regulation of long-term synaptic potentiation-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	HMGCR →	-1.057	-1.817	.003	<.001	3	4
BLOOD_Lymphoma	PIGC →	-0.549	-1.912	<.001	<.001	3	4
LUNG_NSCLC_LUSC	SLC35G1 →	-1.115	-0.998	.005	.002	3	4
LUNG_SCLC	ANKH →	+1.945	+1.717	.001	<.001	3	4
LARGE_INTESTINE	PLA2G4A →	-1.608	-0.939	.006	<.001	3	3
LARGE_INTESTINE	TATDN1 →	-0.633	-0.703	.009	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HMGCR by Positive regulation of long-term synaptic potentiation activity — BLOOD_Myeloma

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