Positive regulation of long-term synaptic potentiation

Across TCGA cell cohorts, RNA activity of the Positive regulation of long-term synaptic potentiation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPC2, ABCG8, and SELPLG, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of long-term synaptic potentiation activity versus NPC2 in SKIN (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NPC2 →	+0.841	+0.251	.004	.003	2	5
CNS	ABCG8 →	-0.020	-0.445	.005	.007	3	3
BLOOD_Myeloma	SELPLG →	+1.975	+1.232	.001	.001	3	3
CNS	ACTR3B →	-0.696	-0.384	.002	.009	2	4
BREAST	FRG1 →	+0.749	+0.603	.002	<.001	3	3
BREAST	TIMM23 →	+0.405	+0.517	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900273 vs NPC2 — SKIN

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