Positive regulation of RIG-I signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of RIG-I signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYNPO2, VPS26AP1, and FAM13C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of RIG-I signaling pathway activity versus SYNPO2 in HNSC (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SYNPO2 →	-0.899	-0.122	.003	.001	3	5
HNSC	VPS26AP1 →	+0.588	+0.190	.001	<.001	3	5
GBM	FAM13C →	-0.575	-0.221	<.001	.001	3	4
HNSC	GRK5 →	-0.592	-0.189	.002	<.001	3	4
HNSC	NHLRC4 →	-0.471	-0.163	.003	.004	3	4
BRCA	CBX7 →	-0.392	-0.139	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900246 vs SYNPO2 — HNSC

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