Regulation of synaptic vesicle endocytosis

Across TCGA cell cohorts, RNA activity of the Regulation of synaptic vesicle endocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MPP1, TMEM154, and SPRED3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MPP1 grouped by Regulation of synaptic vesicle endocytosis-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MPP1 →	-1.853	-0.206	.002	.003	3	4
BLOOD_Leukemia	TMEM154 →	-1.438	-0.184	<.001	<.001	3	4
LUNG_NSCLC_LUAD	SPRED3 →	-0.921	-0.187	.002	.009	3	4
UPPER_AERODIGESTIVE_TRACT	KCTD12 →	-2.066	-0.178	<.001	.009	3	4
LIVER	SEC22B →	-0.730	-0.283	.008	.003	3	4
LUNG_SCLC	URB2 →	+0.887	+0.251	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MPP1 by Regulation of synaptic vesicle endocytosis activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →