Regulation of synaptic vesicle endocytosis

Across TCGA cell cohorts, RNA activity of the Regulation of synaptic vesicle endocytosis pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR43, FOXP2, and KRI1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of synaptic vesicle endocytosis activity versus WDR43 in OVARY (Pearson r = -0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	WDR43 →	-0.760	-0.217	<.001	<.001	3	6
LUNG_SCLC	FOXP2 →	-1.319	-0.221	.001	<.001	3	5
CNS	KRI1 →	-0.714	-0.262	<.001	.001	3	5
OVARY	URB2 →	-1.032	-0.214	<.001	.003	3	5
LARGE_INTESTINE	NOP58 →	-0.894	-0.278	<.001	<.001	3	5
LARGE_INTESTINE	CCNJ →	-0.619	-0.186	.003	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900242 vs WDR43 — OVARY

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