Negative regulation of amyloid-beta clearance

Across TCGA cell cohorts, RNA activity of the Negative regulation of amyloid-beta clearance pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DAPP1, IL6ST, and SAPCD2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DAPP1 grouped by Negative regulation of amyloid-beta clearance-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	DAPP1 →	+2.667	+0.819	<.001	.005	3	5
BREAST	IL6ST →	-1.224	-0.691	.004	.004	3	4
BLOOD_Leukemia	SAPCD2 →	-0.834	-0.874	<.001	<.001	3	4
OESOPHAGUS	KCNRG →	-0.336	-0.872	.001	.005	3	4
LUNG_SCLC	ALDH1L2 →	-2.174	-1.565	<.001	<.001	3	4
URINARY_TRACT	SCN1B →	-1.867	-0.403	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DAPP1 by Negative regulation of amyloid-beta clearance activity — BLOOD_Myeloma

Explore this box plot interactively →