Regulation of amyloid-beta clearance

Across TCGA patient cohorts, RNA activity of the Regulation of amyloid-beta clearance pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNRIP1, CCN4, and MILR1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of amyloid-beta clearance activity versus CNRIP1 in OV (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CNRIP1 →	+0.697	+0.125	<.001	<.001	3	6
OV	CCN4 →	+1.610	+0.148	<.001	<.001	3	6
LSCC	MILR1 →	+0.469	+0.121	<.001	.004	3	6
BRCA	LOXL3 →	+0.554	+0.319	.002	.006	3	5
OV	TGFB1I1 →	+1.005	+0.118	.001	<.001	3	5
OV	MGP →	+1.572	+0.131	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900221 vs CNRIP1 — OV

Explore this scatter interactively →