Regulation of oocyte maturation

Across TCGA patient cohorts, RNA activity of the Regulation of oocyte maturation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLTA, ANKRD49P1, and MOB3B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of oocyte maturation activity versus CLTA in LSCC (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CLTA →	+0.720	+0.695	<.001	.003	3	3
LSCC	ANKRD49P1 →	-0.450	-0.848	<.001	<.001	3	3
CCRCC	MOB3B →	+0.507	+0.581	.006	.004	3	3
PDAC	PTPRJ →	+0.459	+0.811	<.001	<.001	3	3
GBM	SEMA7A →	+0.696	+0.628	.002	.002	3	3
GBM	ZBTB20 →	-0.332	-0.456	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900193 vs CLTA — LSCC

Explore this scatter interactively →