Regulation of oocyte maturation

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of oocyte maturation pathway differs between tumor and matched normal tissue in 14 of the 18 cancer types tested.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as PRAD, show the opposite pattern, with lower activity in tumor tissue.

KIRP, KIRC, and KICH show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KIRP	Male	II,III,IV	+0.147	<.001	11	view →
KIRC	Male	IV	+0.109	<.001	11	view →
KICH	Female	II,III,IV	+0.177	<.001	10	view →
HNSC	Male	All	+0.095	<.001	10	view →
LUSC	Male	II,III,IV	+0.122	<.001	7	view →
UCEC	All	II,III,IV	+0.129	<.001	6	view →
LIHC	Male	III,IV	+0.126	<.001	6	view →
BRCA	All	III,IV	+0.111	<.001	6	view →
LUAD	Female	II,III,IV	+0.058	<.001	6	view →
BLCA	Female	All	+0.048	.035	5	view →
COAD	All	II,III,IV	+0.037	.004	5	view →
ESCA	All	All	+0.104	<.001	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 14 lineages.

GO:1900193–KIRP

Open the KIRP breakdown →