Regulation of oocyte maturation

Across TCGA cell cohorts, RNA activity of the Regulation of oocyte maturation pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AURKA, CD93, and CPSF2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AURKA grouped by Regulation of oocyte maturation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	AURKA →	-0.372	-1.224	<.001	<.001	3	8
OVARY	CD93 →	+0.350	+1.227	.001	<.001	3	4
SKIN	CPSF2 →	+0.174	+0.224	.002	.001	3	4
OVARY	PTPRS →	+0.147	+1.115	.002	.003	2	4
OVARY	PITX3 →	+0.265	+1.245	.005	.001	3	3
OVARY	D2HGDH →	+0.311	+1.086	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AURKA by Regulation of oocyte maturation activity — OVARY

Explore this box plot interactively →