Regulation of oocyte maturation

Across TCGA cell cohorts, RNA activity of the Regulation of oocyte maturation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS16, SRSF4, and SESN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPS16 grouped by Regulation of oocyte maturation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RPS16 →	-0.727	-0.990	<.001	.006	3	4
CNS	SRSF4 →	+0.811	+1.235	.008	.006	2	4
STOMACH	SESN1 →	-1.498	-0.237	<.001	.005	3	3
SOFT_TISSUE	ZBTB1 →	+0.875	+0.300	.007	.002	3	3
SOFT_TISSUE	CCDC151 →	+1.500	+0.369	<.001	<.001	3	3
OESOPHAGUS	ATM →	-1.501	-0.370	.009	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPS16 by Regulation of oocyte maturation activity — BREAST

Explore this box plot interactively →