Regulation of defense response to fungus

Across TCGA cell cohorts, RNA activity of the Regulation of defense response to fungus pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TOMM34, DUSP12, and TMEM222, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TOMM34 grouped by Regulation of defense response to fungus-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TOMM34 →	-0.604	-0.787	.002	<.001	3	4
LUNG_NSCLC_LUAD	DUSP12 →	-0.494	-0.902	.007	.005	3	4
SKIN	TMEM222 →	-0.281	-0.731	<.001	.009	3	4
LUNG_NSCLC_LUSC	TCP1 →	-1.032	-1.603	.009	<.001	3	4
CNS	STPG1 →	-0.837	-1.005	.001	.003	3	4
OVARY	FPGS →	-0.445	-0.867	.007	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TOMM34 by Regulation of defense response to fungus activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →