Regulation of hyaluronan biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of hyaluronan biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLTC, SRP68, and SLC50A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLTC grouped by Regulation of hyaluronan biosynthetic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CLTC →	-0.550	-0.431	<.001	.003	3	5
LUNG_NSCLC_LUAD	SRP68 →	-0.390	-0.330	.009	.009	3	5
UPPER_AERODIGESTIVE_TRACT	SLC50A1 →	+0.959	+0.333	.002	.002	3	4
LUNG_NSCLC_LUAD	SLC30A4 →	-0.736	-0.379	<.001	.002	3	4
LUNG_NSCLC_LUAD	MRC2 →	-1.666	-0.259	.001	.004	3	4
LUNG_NSCLC_LUAD	OVOL2 →	+1.544	+0.344	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLTC by Regulation of hyaluronan biosynthetic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →