Regulation of hyaluronan biosynthetic process

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of hyaluronan biosynthetic process pathway differs between tumor and matched normal tissue in 14 of the 18 cancer types tested.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KIRP and KICH, show the opposite pattern, with lower activity in tumor tissue.

KIRP, THCA, and LIHC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KIRP	Male	All	−0.141	<.001	11	view →
THCA	Male	All	+0.154	<.001	9	view →
LIHC	Female	II,III,IV	+0.127	<.001	8	view →
HNSC	All	II,III,IV	+0.051	<.001	7	view →
STAD	Male	II,III,IV	+0.066	.001	4	view →
CHOL	All	All	+0.162	<.001	3	view →
BLCA	Male	III,IV	+0.102	.015	3	view →
KICH	Male	II,III,IV	−0.086	.002	3	view →
LUAD	All	All	−0.048	<.001	3	view →
UCEC	All	All	−0.048	.019	2	view →
PRAD	All	All	+0.028	.006	2	view →
BRCA	All	All	−0.019	.034	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 14 lineages.

GO:1900125–KIRP

Open the KIRP breakdown →