Regulation of hyaluronan biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of hyaluronan biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HNRNPA1, TBC1D17, and CCDC80, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of hyaluronan biosynthetic process activity versus HNRNPA1 in BONE (Pearson r = -0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	HNRNPA1 →	-0.728	-0.351	<.001	.002	3	8
BREAST	TBC1D17 →	+0.765	+0.163	.001	<.001	3	6
BONE	CCDC80 →	+4.096	+0.392	<.001	<.001	3	6
LIVER	HIF1A →	+1.852	+0.278	.006	.007	3	5
URINARY_TRACT	SHISA4 →	+1.232	+0.268	.001	.001	3	5
OVARY	HDHD5 →	-1.102	-0.195	.003	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900125 vs HNRNPA1 — BONE

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