Positive regulation of execution phase of apoptosis

Across TCGA cell cohorts, RNA activity of the Positive regulation of execution phase of apoptosis pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN1A, RMI1, and TAF5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDKN1A grouped by Positive regulation of execution phase of apoptosis-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CDKN1A →	-1.970	-1.132	.002	.001	3	5
SOFT_TISSUE	RMI1 →	+0.777	+1.078	<.001	<.001	3	5
OESOPHAGUS	TAF5 →	+0.652	+0.207	.005	.001	3	5
CNS	ZMAT3 →	-1.246	-1.102	<.001	.001	3	4
SOFT_TISSUE	NSMCE2 →	+0.693	+0.918	<.001	.006	3	4
SOFT_TISSUE	SASS6 →	+0.760	+1.473	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDKN1A by Positive regulation of execution phase of apoptosis activity — CNS

Explore this box plot interactively →