Positive regulation of execution phase of apoptosis

Across TCGA cell cohorts, RNA activity of the Positive regulation of execution phase of apoptosis pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VPS37A, CEP104, and C11orf68, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of execution phase of apoptosis activity versus VPS37A in OVARY (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	VPS37A →	-0.673	-0.194	.005	.004	3	6
SKIN	CEP104 →	-0.560	-0.183	.002	.009	3	5
CNS	C11orf68 →	-0.900	-0.252	.004	.002	3	4
BLOOD_Leukemia	PLPBP →	-0.810	-0.100	<.001	.001	3	4
LIVER	DBI →	-1.179	-0.253	.006	.007	2	5
LUNG_SCLC	DBR1 →	-0.419	-0.176	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900119 vs VPS37A — OVARY

Explore this scatter interactively →