Negative regulation of execution phase of apoptosis

Across TCGA patient cohorts, RNA activity of the Negative regulation of execution phase of apoptosis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MMP2, CCNT1, and ZEB2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of execution phase of apoptosis activity versus MMP2 in GBM (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MMP2 →	-0.547	-0.063	.002	.001	2	7
LSCC	CCNT1 →	+0.276	+0.060	<.001	<.001	3	6
LSCC	ZEB2 →	-0.291	-0.061	<.001	<.001	3	6
OV	TLN1 →	-0.273	-0.070	.003	.003	3	5
LUAD	RUNX1_T14 →	-0.472	-0.054	.003	.003	3	5
LUAD	SGCD →	-0.420	-0.046	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900118 vs MMP2 — GBM

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