Negative regulation of execution phase of apoptosis

Across TCGA cell cohorts, RNA activity of the Negative regulation of execution phase of apoptosis pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THSD4, NRBF2, and NDUFAF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of execution phase of apoptosis activity versus THSD4 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	THSD4 →	-1.410	-0.077	.008	.002	3	4
BLOOD_Leukemia	NRBF2 →	+0.545	+0.082	<.001	<.001	3	4
BREAST	NDUFAF1 →	-0.752	-0.109	<.001	<.001	3	4
BLOOD_Leukemia	DUSP12 →	+0.512	+0.074	.001	.001	3	3
STOMACH	RIMS3 →	+1.888	+0.084	.001	.003	3	3
STOMACH	CMC1 →	-1.630	-0.112	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900118 vs THSD4 — UPPER_AERODIGESTIVE_TRACT

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