Negative regulation of nodal signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of nodal signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ERGIC2, SND1, and PDIA4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of nodal signaling pathway activity versus ERGIC2 in CCRCC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ERGIC2 →	+0.447	+0.148	<.001	<.001	3	5
CCRCC	SND1 →	+0.137	+0.082	<.001	<.001	3	5
CCRCC	PDIA4 →	+0.386	+0.121	<.001	<.001	3	5
CCRCC	ALDH18A1 →	+0.415	+0.085	<.001	<.001	3	4
BRCA	TMED2 →	+0.383	+0.066	<.001	.002	3	4
BRCA	CD63 →	+0.526	+0.073	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900108 vs ERGIC2 — CCRCC

Explore this scatter interactively →