Negative regulation of nodal signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of nodal signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLU, LRRIQ1, and MYORG, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of nodal signaling pathway activity versus CLU in UCEC (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CLU →	+2.638	+0.253	<.001	.007	3	1
UCEC	LRRIQ1 →	-1.648	-0.197	<.001	.003	3	1
UCEC	MYORG →	-0.716	-0.211	.001	.005	3	1
UCEC	SNORA16B →	+1.104	+0.211	<.001	.005	3	1
UCEC	MIR539 →	+0.922	+0.206	.001	.008	3	1
UCEC	GGTA1 →	+1.164	+0.237	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900108 vs CLU — UCEC

Explore this scatter interactively →