Positive regulation of endoplasmic reticulum unfolded protein response

Across TCGA patient cohorts, RNA activity of the Positive regulation of endoplasmic reticulum unfolded protein response pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FGD3, PLXNC1_S978, and G3BP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of endoplasmic reticulum unfolded protein response activity versus FGD3 in BRCA (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FGD3 →	+0.788	+0.058	<.001	<.001	3	6
CCRCC	PLXNC1_S978 →	+0.652	+0.063	<.001	<.001	3	6
BRCA	G3BP1 →	-0.195	-0.058	.002	<.001	3	6
LSCC	GPKOW →	-0.290	-0.081	<.001	<.001	3	6
COAD	SERBP1 →	-0.231	-0.043	<.001	<.001	3	6
COAD	WBP11 →	-0.160	-0.032	.007	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900103 vs FGD3 — BRCA

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