Positive regulation of endoplasmic reticulum unfolded protein response

Across TCGA patient cohorts, RNA activity of the Positive regulation of endoplasmic reticulum unfolded protein response pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BBS4, SLC2A11, and ZNF767P, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of endoplasmic reticulum unfolded protein response activity versus BBS4 in PDAC (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	BBS4 →	-0.245	-0.246	.003	<.001	3	4
HNSC	SLC2A11 →	-0.587	-0.236	.001	.001	3	3
HNSC	ZNF767P →	-0.506	-0.179	<.001	<.001	3	3
HNSC	RNASEH2B →	-0.448	-0.219	.001	.003	3	3
HNSC	TET1 →	-0.716	-0.167	<.001	<.001	3	3
HNSC	MSI2 →	-0.611	-0.203	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900103 vs BBS4 — PDAC

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