Positive regulation of endoplasmic reticulum unfolded protein response

Across TCGA cell cohorts, RNA activity of the Positive regulation of endoplasmic reticulum unfolded protein response pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FLT3LG, SLC46A3, and PRKCH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FLT3LG grouped by Positive regulation of endoplasmic reticulum unfolded protein response-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	FLT3LG →	+1.475	+1.394	.003	.009	3	4
STOMACH	SLC46A3 →	+1.906	+1.339	<.001	<.001	3	3
STOMACH	PRKCH →	+2.211	+1.402	.001	<.001	3	3
OESOPHAGUS	AOPEP →	+0.951	+0.923	.002	.005	3	3
LARGE_INTESTINE	KAT2B →	+0.892	+0.923	.004	.009	3	3
BLOOD_Myeloma	PALLD →	+1.719	+1.542	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FLT3LG by Positive regulation of endoplasmic reticulum unfolded protein response activity — BONE

Explore this box plot interactively →