Negative regulation of endoplasmic reticulum unfolded protein response

Across TCGA cell cohorts, RNA activity of the Negative regulation of endoplasmic reticulum unfolded protein response pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EEF1B2, MDH2, and CALHM6, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of endoplasmic reticulum unfolded protein response activity versus EEF1B2 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	EEF1B2 →	-1.307	-0.242	.004	.006	2	7
SKIN	MDH2 →	-1.167	-0.343	<.001	.003	3	6
CNS	CALHM6 →	+1.199	+0.257	.008	.001	3	6
LUNG_SCLC	ZNF711 →	-1.335	-0.215	.002	.001	3	6
LUNG_SCLC	CNBP →	-0.527	-0.246	.001	.002	3	6
BLOOD_Leukemia	CISD3 →	-0.863	-0.136	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900102 vs EEF1B2 — UPPER_AERODIGESTIVE_TRACT

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