Positive regulation of G1/S transition of mitotic cell cycle

Across TCGA patient cohorts, RNA activity of the Positive regulation of G1/S transition of mitotic cell cycle pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEPTIN4, IGFBP7, and NR4A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of G1/S transition of mitotic cell cycle activity versus SEPTIN4 in GBM (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEPTIN4 →	-0.986	-0.268	<.001	<.001	3	6
PDAC	IGFBP7 →	-0.579	-0.198	<.001	<.001	3	6
LUAD	NR4A1 →	-1.012	-0.163	<.001	<.001	3	6
GBM	EGFR →	+1.939	+0.210	.005	<.001	3	6
LUAD	TK1 →	+0.752	+0.226	.002	<.001	3	6
OV	IL20RB-AS1 →	+0.285	+0.260	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900087 vs SEPTIN4 — GBM

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