Positive regulation of G1/S transition of mitotic cell cycle

Across TCGA cell cohorts, RNA activity of the Positive regulation of G1/S transition of mitotic cell cycle pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UPK2, ITGB6, and GEMIN5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UPK2 grouped by Positive regulation of G1/S transition of mitotic cell cycle-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	UPK2 →	+0.484	+0.309	.008	.003	2	6
PANCREAS	ITGB6 →	+2.943	+0.325	.002	.008	3	5
PANCREAS	GEMIN5 →	-0.852	-0.307	.001	<.001	3	5
URINARY_TRACT	DTX4 →	+3.222	+0.302	.002	.003	3	5
URINARY_TRACT	NEDD9 →	+3.560	+0.311	.002	.002	3	5
LARGE_INTESTINE	NUP88 →	-0.852	-0.333	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UPK2 by Positive regulation of G1/S transition of mitotic cell cycle activity — SOFT_TISSUE

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