Positive regulation of G1/S transition of mitotic cell cycle

Across TCGA cell cohorts, RNA activity of the Positive regulation of G1/S transition of mitotic cell cycle pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CALD1, ATP1B1, and CAMK4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of G1/S transition of mitotic cell cycle activity versus CALD1 in BREAST (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CALD1 →	+2.301	+0.160	.004	.003	3	5
STOMACH	ATP1B1 →	-2.951	-0.326	.007	.007	3	5
BLOOD_Leukemia	CAMK4 →	+2.070	+0.285	<.001	<.001	3	5
BREAST	XBP1 →	-1.850	-0.191	.003	.003	3	4
BREAST	ETS1 →	+2.766	+0.189	<.001	.005	3	4
LARGE_INTESTINE	RDX →	+3.252	+0.227	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900087 vs CALD1 — BREAST

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