Negative regulation of cellular response to insulin stimulus

Across TCGA cell cohorts, RNA activity of the Negative regulation of cellular response to insulin stimulus pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTMA, GMCL1, and PPP1R8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cellular response to insulin stimulus activity versus PTMA in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PTMA →	-1.005	-1.324	<.001	.001	3	6
CNS	GMCL1 →	-0.507	-0.871	<.001	.001	3	5
SKIN	PPP1R8 →	-0.361	-0.889	.001	.004	3	5
PANCREAS	ETF1 →	-0.545	-1.060	.004	.003	3	5
BREAST	TMEM265 →	+1.991	+0.876	<.001	.009	3	5
LARGE_INTESTINE	NOA1 →	-0.597	-0.564	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900077 vs PTMA — UPPER_AERODIGESTIVE_TRACT

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