Negative regulation of cellular response to insulin stimulus

Across TCGA cell cohorts, RNA activity of the Negative regulation of cellular response to insulin stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PTPN1, PDAP1, and RPS28, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of cellular response to insulin stimulus activity versus PTPN1 in PANCREAS (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PTPN1 →	+1.485	+1.137	<.001	.001	3	15
URINARY_TRACT	PDAP1 →	-2.211	-1.695	.004	<.001	3	12
URINARY_TRACT	RPS28 →	-1.808	-1.460	<.001	.001	3	12
URINARY_TRACT	EIF4H →	-2.133	-1.656	.002	<.001	3	11
LUNG_NSCLC_LUSC	LSM7 →	-0.712	-0.948	<.001	.009	2	12
URINARY_TRACT	ANP32A →	-2.280	-1.555	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900077 vs PTPN1 — PANCREAS

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