Regulation of cellular response to insulin stimulus

Across TCGA cell cohorts, RNA activity of the Regulation of cellular response to insulin stimulus pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBE2E2, C5, and SLIRP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UBE2E2 grouped by Regulation of cellular response to insulin stimulus-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	UBE2E2 →	-0.145	-0.738	<.001	.001	3	3
KIDNEY	C5 →	-0.191	-0.707	<.001	.007	3	3
BLOOD_Myeloma	SLIRP →	-0.326	-0.189	.003	.005	3	3
BLOOD_Leukemia	LMNA →	-0.232	-1.135	.002	.003	3	3
BLOOD_Leukemia	INMT →	-0.223	-1.096	<.001	.001	3	3
SKIN	GCNT1 →	+0.194	+0.941	.006	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UBE2E2 by Regulation of cellular response to insulin stimulus activity — BREAST

Explore this box plot interactively →