Regulation of cellular response to insulin stimulus

Across TCGA cell cohorts, RNA activity of the Regulation of cellular response to insulin stimulus pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPUSD3, TBC1D3C, and TJP3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPUSD3 grouped by Regulation of cellular response to insulin stimulus-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RPUSD3 →	-0.908	-0.165	.005	.002	3	4
BLOOD_Myeloma	TBC1D3C →	-0.828	-0.248	.006	.001	3	4
LARGE_INTESTINE	TJP3 →	+2.502	+0.170	.001	.005	3	4
LARGE_INTESTINE	CANT1 →	+1.102	+0.139	.006	.008	3	4
LARGE_INTESTINE	ZNF396 →	+0.671	+0.210	<.001	<.001	3	4
LARGE_INTESTINE	ZSCAN16 →	+0.681	+0.171	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPUSD3 by Regulation of cellular response to insulin stimulus activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →