Regulation of cellular response to insulin stimulus

Across TCGA cell cohorts, RNA activity of the Regulation of cellular response to insulin stimulus pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHLPP1, LRPPRC, and E2F2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cellular response to insulin stimulus activity versus PHLPP1 in BLOOD_Myeloma (Pearson r = -0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PHLPP1 →	-1.730	-1.441	.004	<.001	3	6
LIVER	LRPPRC →	-1.003	-1.493	.009	<.001	3	6
LARGE_INTESTINE	E2F2 →	-0.873	-0.818	<.001	.002	3	5
UPPER_AERODIGESTIVE_TRACT	MDH2 →	-0.703	-1.250	.002	.001	3	5
LIVER	FAM214B →	+2.058	+1.489	.001	<.001	3	5
LUNG_SCLC	FH →	-0.575	-0.930	.004	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900076 vs PHLPP1 — BLOOD_Myeloma

Explore this scatter interactively →