Negative regulation of protein K63-linked ubiquitination

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein K63-linked ubiquitination pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RUVBL2, UBA5, and EIF2A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein K63-linked ubiquitination activity versus RUVBL2 in LUAD (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RUVBL2 →	+0.175	+0.076	<.001	<.001	3	4
CCRCC	UBA5 →	+0.321	+0.084	<.001	.002	3	4
LUAD	EIF2A →	+0.176	+0.065	<.001	<.001	3	4
CCRCC	LARP1_T449 →	+0.331	+0.065	<.001	.008	3	4
OV	NIBAN2_S681 →	+1.165	+0.089	<.001	<.001	3	4
BRCA	ZDHHC8_S526 →	-0.640	-0.059	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900045 vs RUVBL2 — LUAD

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